iPTMnet Report for O14974 (PPP1R12A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14974 / MYPT1_HUMAN
Protein Name Protein phosphatase 1 regulatory subunit 12A
Gene Name Name: PPP1R12A
Synonyms:MBS,MYPT1;
Organism Homo sapiens (Human)

PRO ID PR:O14974
DAG View
PRO Name protein phosphatase 1 regulatory subunit 12A (human)
Definition A protein phosphatase 1 regulatory subunit 12A that is encoded in the genome of human.
Short Label hPPP1R12A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14974 (PPP1R12A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K9 Acetylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus   RLIMS-P 29262732
T22 Phosphorylation PhosphoSitePlus
T34 Phosphorylation RLIMS-P 11068043
Y68 Phosphorylation PhosphoSitePlus
T234 Phosphorylation PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus
S299 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
S304 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus
S365 Phosphorylation PhosphoSitePlus
S379 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
T381 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 28657654, 32119511, 32295844, 28411811, 31637018, 32574038, 32938750, 34019870, 35132862, 20305658, 31373491, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
T385 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S387 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
T388 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
T396 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
T399 O-Glycosylation GlyGen 32574038
S401 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
T406 Phosphorylation PhosphoSitePlus
T408 Phosphorylation PhosphoSitePlus
S409 O-Glycosylation GlyGen 22661428
S409 Phosphorylation PhosphoSitePlus
T416 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
T416 Phosphorylation PhosphoSitePlus
T417 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T419 Phosphorylation PhosphoSitePlus
S422 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 20068231
S432 Phosphorylation P06493 (CDK1) neXtProt   PhosphoSitePlus   UniProt 18477460
K442 Acetylation PhosphoSitePlus
K442 Methylation PhosphoSitePlus
T443 Phosphorylation O75116 (ROCK2) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 10579722
S445 Phosphorylation O60285 (NUAK1) , O95835 (LATS1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 18088087, 18669648, 23186163, ...22641346, 20354225, 30446640, 24171924
Y446 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T453 Phosphorylation PhosphoSitePlus
K456 Acetylation PhosphoSitePlus
K460 Acetylation PhosphoSitePlus
T464 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
T464 Phosphorylation PhosphoSitePlus
S470 Phosphorylation PhosphoSitePlus
S472 Phosphorylation O60285 (NUAK1) PhosphoSitePlus   RLIMS-P   Signor   UniProt 29154753, 20354225, 18094049
S473 Phosphorylation P06493 (CDK1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 22641346, 29154753, 18477460, ...18669648, 23186163, 31416392
S477 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S477 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S478 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S479 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S479 Phosphorylation PhosphoSitePlus
S489 Phosphorylation PhosphoSitePlus
Y496 Phosphorylation PhosphoSitePlus
T500 Phosphorylation PhosphoSitePlus
S507 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 18088087, 28827520, ...18669648, 31138649, 31416392, 23186163
T508 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S509 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S520 Phosphorylation PhosphoSitePlus
S525 Phosphorylation PhosphoSitePlus
Y528 Phosphorylation PhosphoSitePlus
T529 Phosphorylation PhosphoSitePlus
K539 Methylation PhosphoSitePlus
S541 Phosphorylation PhosphoSitePlus
S542 Phosphorylation PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus
T548 Phosphorylation PhosphoSitePlus
Y549 Phosphorylation PhosphoSitePlus
K551 Methylation PhosphoSitePlus
S552 Phosphorylation PhosphoSitePlus
S554 Phosphorylation PhosphoSitePlus
S564 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 28657654, 32119511, 32295844, 28411811, 31637018, 32574038, 32938750, 34019870, 35132862, 20305658, 31373491, 27655845, 34846842, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S565 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S566 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 28657654, 32119511, 32295844, 28411811, 31637018, 32574038, 32938750, 34019870, 35132862, 20305658, 31373491, 27655845, 34846842, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S569 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
T570 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 28657654, 32119511, 32295844, 28411811, 31637018, 32574038, 32938750, 34019870, 35132862, 20305658, 31373491, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
T571 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 28657654, 32119511, 32295844, 28411811, 31637018, 32574038, 32938750, 34019870, 35132862, 20305658, 31373491, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
T571 Phosphorylation PhosphoSitePlus
S572 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 34846842, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
T573 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 28657654, 32119511, 32295844, 28411811, 31637018, 32574038, 32938750, 34019870, 35132862, 20305658, 31373491, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
T575 Phosphorylation PhosphoSitePlus
T577 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 28657654, 32119511, 32295844, 28411811, 31637018, 32574038, 32938750, 34019870, 35132862, 20305658, 31373491, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S578 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 28657654, 32119511, 32295844, 28411811, 31637018, 32574038, 32938750, 34019870, 35132862, 20305658, 31373491, 27655845, 34846842, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S578 Phosphorylation PhosphoSitePlus
S585 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 28657654, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 31373491, 27655845, 34846842, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S585 Phosphorylation PhosphoSitePlus
S588 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S589 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 28657654, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 31373491, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
T590 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
T592 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
T594 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
T597 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S601 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S601 Phosphorylation P06493 (CDK1) neXtProt   UniProt 18477460
S607 Phosphorylation PhosphoSitePlus
S608 Phosphorylation PhosphoSitePlus
T609 Phosphorylation PhosphoSitePlus
S618 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S618 Phosphorylation PhosphoSitePlus   UniProt 23186163
T631 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
T631 Phosphorylation PhosphoSitePlus
T637 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S644 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
T645 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
T645 Phosphorylation PhosphoSitePlus
T647 Phosphorylation PhosphoSitePlus
T652 Phosphorylation PhosphoSitePlus
S668 Phosphorylation PhosphoSitePlus   RLIMS-P 31138649, 23516539, 25168281
Y669 Phosphorylation PhosphoSitePlus
T671 Phosphorylation PhosphoSitePlus
S678 Phosphorylation PhosphoSitePlus
S680 Phosphorylation PhosphoSitePlus
S692 Phosphorylation Q13976 (PRKG1) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 15194681, 10567269
S695 Phosphorylation Q13976 (PRKG1) , P17612 (PRKACA) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 22948155, 22530104, 10567269, ...18237278, 19095646, 15194681
T696 Phosphorylation Q09013 (DMPK) , P04049 (RAF1) , P17612 (PRKACA) , O75116 (ROCK2) , Q13464 (ROCK1) , Q13418 (ILK) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24712327, 23345589, 19879105, ...16608882, 19997641, 32679023, 28300193, 32421147, 22869619, 11384979, 23516539, 28387646, 8662509, 17525332, 19806255, 18648664, 15281089, 20130087, 25980620, 15665049, 29511289, 22948155, 23186163, 22155728, 18669648, 15475516, 24815187, 24356468, 11719507, 15124925, 27725371, 10579722, 18423375, 18237278, 33802280, 19701943, 12030846, 12919947, 15194681, 22947248, 31834925, 11287000, 28827520, 23161543, 21850162, 23362260, 23308222, 24993595, 19531490, 19095646, 15723050, 20801872
T700 Phosphorylation PhosphoSitePlus
T702 Phosphorylation PhosphoSitePlus
T710 Phosphorylation Q13418 (ILK) PhosphoSitePlus   Signor 12030846
S716 Phosphorylation PhosphoSitePlus
T717 Phosphorylation PhosphoSitePlus
T719 Phosphorylation PhosphoSitePlus
K743 Acetylation PhosphoSitePlus
S746 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
T748 Phosphorylation PhosphoSitePlus
S749 Phosphorylation PhosphoSitePlus
Y754 Phosphorylation PhosphoSitePlus
K755 Acetylation PhosphoSitePlus
Y758 Phosphorylation PhosphoSitePlus
S759 Phosphorylation PhosphoSitePlus
T761 Phosphorylation PhosphoSitePlus
Y762 Phosphorylation PhosphoSitePlus
T765 Phosphorylation PhosphoSitePlus
Y766 Phosphorylation PhosphoSitePlus
Y769 Phosphorylation PhosphoSitePlus
S773 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
T774 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S775 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S776 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S777 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
T778 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
T779 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S781 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S781 Phosphorylation PhosphoSitePlus
S782 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S783 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S785 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
T786 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S788 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S789 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S790 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S790 Phosphorylation PhosphoSitePlus
Y792 Phosphorylation PhosphoSitePlus
S794 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S794 Phosphorylation PhosphoSitePlus
S795 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S795 Phosphorylation PhosphoSitePlus
S802 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S802 Phosphorylation PhosphoSitePlus
T807 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S808 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
Y810 Phosphorylation PhosphoSitePlus
S811 Phosphorylation PhosphoSitePlus
S835 O-Glycosylation GlyGen 23301498, 35138101, 30620550, ...31492838, 21740066, 35289036, 29351928, 22661428, 29237092, 18840611, 27114449, 34725712, 31373491, 32119511, 32295844, 28411811, 31637018, 32574038, 34019870, 35132862, 20305658, 28657654, 27655845, 33214551, 30379171, 30059200, 25367160, 35254053, 34019948, 22967762, 36240223
S839 Phosphorylation PhosphoSitePlus
S852 Phosphorylation P17612 (PRKACA) , O75116 (ROCK2) , Q13976 (PRKG1) , Q9Y5S2 (CDC42BPB) , Q13464 (ROCK1) neXtProt   PRO   PhosphoSitePlus   RLIMS-P   UniProt 11331307, 10926869, 21457715, ...15676024, 22948155, 10567269, 10579722, 10947843, 15194681, 20801872
T853 Phosphorylation P17612 (PRKACA) , Q13464 (ROCK1) , Q04759 (PRKCQ) neXtProt   PhosphoSitePlus   RLIMS-P 24712327, 23345589, 16608882, ...15226371, 23516539, 24100445, 18648664, 19255442, 20130087, 25980620, 22155728, 24815187, 28191820, 22948155, 27725371, 18374184, 33802280, 28278256, 22020732, 22947248, 31834925, 28827520, 21850162, 23362260, 23308222, 31138649, 19531490, 19095646
S856 Phosphorylation PhosphoSitePlus
T859 Phosphorylation PhosphoSitePlus
S862 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S871 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 20068231, ...19690332
T873 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S877 Phosphorylation PhosphoSitePlus
T884 Phosphorylation PhosphoSitePlus
S886 Phosphorylation PhosphoSitePlus
S888 Phosphorylation PhosphoSitePlus
Y890 Phosphorylation phospho.ELM   PhosphoSitePlus 15144186
T892 Phosphorylation PhosphoSitePlus
S893 Phosphorylation PhosphoSitePlus
S894 Phosphorylation PhosphoSitePlus
S896 Phosphorylation PhosphoSitePlus
Y901 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15144186
S903 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23345589, 23186163
S908 Phosphorylation PhosphoSitePlus   UniProt 23186163
S910 Phosphorylation O60285 (NUAK1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 23186163, 18669648, 20354225, ...18088087
Y911 Phosphorylation phospho.ELM   PhosphoSitePlus 15144186
S912 Phosphorylation PhosphoSitePlus
Y913 Phosphorylation PhosphoSitePlus
Y920 Phosphorylation PhosphoSitePlus
S921 Phosphorylation PhosphoSitePlus
S922 Phosphorylation PhosphoSitePlus
Y936 Phosphorylation PhosphoSitePlus
K945 Ubiquitination PhosphoSitePlus
S978 Phosphorylation PhosphoSitePlus
S995 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1002 Methylation PhosphoSitePlus
K1008 Methylation PhosphoSitePlus
S1029 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S198 Phosphorylation HPRD 20068231
S299 Phosphorylation HPRD 19651622, 18767875, 18669648, ...19664994, 20068231
T305 Phosphorylation HPRD 18767875
T417 Phosphorylation HPRD 18669648
S422 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18212344
T443 Phosphorylation HPRD 19413330, 20166139, 18669648, ...18491316, 20068231
S445 Phosphorylation HPRD 19413330, 18491316, 18088087, ...18767875, 20058876, 19664995, 18669648, 20166139, 20068231
Y446 Phosphorylation HPRD 19413330, 18669648, 15570572, ...20068231
S473 Phosphorylation HPRD 18669648
S477 Phosphorylation HPRD 18669648
S478 Phosphorylation HPRD 18669648
Y496 Phosphorylation HPRD 19901323
S507 Phosphorylation HPRD 18767875, 18669648, 18088087, ...18212344, 17924679
T508 Phosphorylation HPRD 18669648
S509 Phosphorylation HPRD 18669648
S585 Phosphorylation HPRD 20068231
S588 Phosphorylation HPRD 20068231
T590 Phosphorylation HPRD 20068231
T593 Phosphorylation HPRD 20068231
S668 Phosphorylation HPRD 18212344
S695 Phosphorylation HPRD 18212344
T696 Phosphorylation Q13418 (ILK) , Q09013 (DMPK) , Q13464 (ROCK1) HPRD 18212344, 18767875, 11931630, ...12600888, 12220642, 18669648, 10601309, 18077418
T853 Phosphorylation Q13464 (ROCK1) , O75116 (ROCK2) HPRD 10601309, 12220642, 11931630, ...12600888, 12563012
S856 Phosphorylation HPRD 17081983
T859 Phosphorylation HPRD 17081983
S862 Phosphorylation HPRD 18669648, 19415658
S871 Phosphorylation HPRD 18669648, 19415658, 20068231, ...18452278
T873 Phosphorylation HPRD 18669648, 18452278
S888 Phosphorylation HPRD 20068231
Y890 Phosphorylation HPRD 15144186
Y901 Phosphorylation HPRD 18669648, 15144186
S908 Phosphorylation HPRD 20058876
S910 Phosphorylation HPRD 18088087, 18669648, 20058876, ...18212344, 19664995
Y911 Phosphorylation HPRD 19901323, 15144186
Y936 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
K551 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S609 Phosphorylation PhosphoSitePlus
T612 Phosphorylation PhosphoSitePlus
S621 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048866 (hPPP1R12A/Phos:1) pS473 PRO
PR:000048867 (hPPP1R12A/Phos:2) pT696 PRO
PR:000048868 (hPPP1R12A/Phos:3) pT696,pS852 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O14974 (PPP1R12A) S507 Q7Z406 (MYH14) inhibited_association eFIP 31138649
Phosphorylation O14974 (PPP1R12A) T696 Q15181 (PPA1) unknown eFIP 25980620
Phosphorylation Q96IZ0 (PAWR) T163 O14974 (PPP1R12A) inhibited_association eFIP 31834925


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T234 A234 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S336 Y336 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S365 L365 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S379 C379 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S409 L409 Biomuta DOID:363 / uterine cancer [ cosmic ]
T419 A419 Biomuta DOID:263 / kidney cancer [ cosmic ]
S432 F432 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T443 M443 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S473 I473 Biomuta DOID:4159 / skin cancer [ cosmic ]
S478 Y478 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T508 S508 Biomuta DOID:4159 / skin cancer [ cosmic ]
S520 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T529 R529 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S542 L542 Biomuta DOID:3571 / liver cancer [ cosmic ]
S554 C554 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S554 F554 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S565 C565 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T590 I590 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
T609 A609 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T631 A631 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T652 I652 Biomuta DOID:4159 / skin cancer [ cosmic ]
T700 S700 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T710 A710 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T761 M761 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y766 C766 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S776 R776 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S789 R789 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T807 P807 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T807 I807 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S852 Y852 Biomuta DOID:363 / uterine cancer [ icgc ]
T853 A853 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T884 M884 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S888 F888 Biomuta DOID:263 / kidney cancer [ cosmic ]
S894 Y894 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S903 A903 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S910 T910 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S978 P978 Biomuta DOID:3571 / liver cancer [ cosmic ]