iPTMnet Report for O14965 (AURKA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14965 / AURKA_HUMAN
Protein Name Aurora kinase A
Gene Name Name: AURKA
Synonyms:AIK;
Organism Homo sapiens (Human)

PRO ID PR:O14965
DAG View
PRO Name aurora kinase A (human)
Definition An aurora kinase A that is encoded in the genome of human.
Short Label hAURKA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14965 (AURKA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation HPRD   PhosphoSitePlus 18691976
S10 Phosphorylation O14965 (AURKA) phospho.ELM   PhosphoSitePlus 16083426
K14 Methylation PhosphoSitePlus
T16 Phosphorylation O14965 (AURKA) phospho.ELM   PhosphoSitePlus 16083426
K23 Ubiquitination PhosphoSitePlus
S41 Phosphorylation O14965 (AURKA) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 16083426
S51 Phosphorylation HPRD   neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 22621899, 17229885, ...26380219, 17895985, 19007248, 20842194
S53 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P 18691976, 22621899, 20842194
S54 Phosphorylation PhosphoSitePlus   RLIMS-P 22621899
K63 Ubiquitination PhosphoSitePlus
S66 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P 18691976, 22621899, 20842194
S67 Phosphorylation O14965 (AURKA) phospho.ELM   PhosphoSitePlus   RLIMS-P 16083426, 22621899, 20842194
K69 Ubiquitination PhosphoSitePlus
K75 Acetylation PhosphoSitePlus
S83 Phosphorylation O14965 (AURKA) HPRD   phospho.ELM   PhosphoSitePlus 16083426, 18691976
S89 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P 22451695
S98 Phosphorylation O14965 (AURKA) phospho.ELM   PhosphoSitePlus   RLIMS-P 16083426, 22621899
K99 Ubiquitination PhosphoSitePlus
S104 Phosphorylation O14965 (AURKA) phospho.ELM   PhosphoSitePlus 16083426
S116 Phosphorylation HPRD   PhosphoSitePlus 20068231
K117 Methylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K125 Acetylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
Y148 Phosphorylation P12931 (SRC) , O14965 (AURKA) phospho.ELM   PhosphoSitePlus   RLIMS-P+ 16083426, 27242098
S226 Phosphorylation O14965 (AURKA) phospho.ELM   PhosphoSitePlus 16083426
K227 Ubiquitination PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
K258 Sumoylation PRO
K258 Ubiquitination PhosphoSitePlus
S266 Phosphorylation O14965 (AURKA) phospho.ELM   PhosphoSitePlus 16083426
S278 Phosphorylation O14965 (AURKA) phospho.ELM   PhosphoSitePlus 16083426
S283 Phosphorylation RLIMS-P 18614302
S284 Phosphorylation PhosphoSitePlus   RLIMS-P 18614302
T287 Phosphorylation Q05513 (PRKCZ) , O14965 (AURKA) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 16083426, 25760707, ...23924325, 14580337, 19668197
T288 Phosphorylation Q13153 (PAK1) , O14965 (AURKA) , P17612 (PRKACA) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 22011530, 21600017, 29568394, ...31920463, 20799978, 18663361, 24901229, 29222185, 27721411, 17102620, 23516487, 20842194, 27863392, 30082913, 33091845, 25645017, 18487071, 32932728, 17895985, 28972102, 31254157, 33674749, 26732741, 28861148, 28592839, 25082261, 25501815, 23755206, 30070631, 16083426, 24195668, 23043539, 15966895, 32804172, 24499673, 26369427, 23678290, 27138904, 21187329, 11039908, 24930769, 24980814, 26134678, 23037716, 29531224, 29262328, 26246606, 21347367, 22904328, 15173575, 28389630, 24867643, 29656197, 31546169, 16785988, 22240781, 23934191, 28869606, 25760707, 25002679, 23924325, 26782714, 14580337, 23213400, 21829699, 13678582, 18662907, 16246726, 19668197, 33771996, 31881080, 25872528, 29556353, 28458622, 22451695, 26729093, 18026198, 23864709, 22529102, 33669244, 26842935, 27624869, 20825672, 29163689, 20603326
T292 Phosphorylation PhosphoSitePlus
Y295 Phosphorylation PhosphoSitePlus
R304 Methylation PhosphoSitePlus
Y334 Phosphorylation RLIMS-P 24867643
S342 Phosphorylation O14965 (AURKA) , Q13153 (PAK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 16083426, 16246726
S369 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332
S391 Phosphorylation O14965 (AURKA) phospho.ELM   PhosphoSitePlus 16083426


O14965 (AURKA) as PTM Enzyme



Substrate Site Score Source PMID
O14777 (NDC80) S55 PhosphoSitePlus 26166783
O14965 (AURKA) S10 PhosphoSitePlus 16083426
O14965 (AURKA) T16 PhosphoSitePlus 16083426
O14965 (AURKA) S41 PhosphoSitePlus 16083426
O14965 (AURKA) S67 PhosphoSitePlus 16083426
O14965 (AURKA) S83 PhosphoSitePlus 16083426
O14965 (AURKA) S98 PhosphoSitePlus 16083426
O14965 (AURKA) S104 PhosphoSitePlus 16083426
O14965 (AURKA) Y148 PhosphoSitePlus 16083426
O14965 (AURKA) S226 PhosphoSitePlus 16083426
O14965 (AURKA) S266 PhosphoSitePlus 16083426
O14965 (AURKA) S278 PhosphoSitePlus 16083426
O14965 (AURKA) T287 PhosphoSitePlus 16083426
O14965 (AURKA) T288 PhosphoSitePlus   RLIMS-P+   Signor 26369427, 24930769, 16083426, ...21600017, 27624869, 24867643, 22904328, 16785988
O14965 (AURKA) S342 PhosphoSitePlus 16083426
O14965 (AURKA) S391 PhosphoSitePlus 16083426
O15143 (ARPC1B) T21 neXtProt   PhosphoSitePlus 20603326
O15350 (TP73) S235 PhosphoSitePlus 22340593
O43521 (BCL2L11) S93 PhosphoSitePlus 23912711
O43521 (BCL2L11) S94 PhosphoSitePlus 23912711
O43521 (BCL2L11) S98 PhosphoSitePlus 23912711
O75496 (GMNN) T25 PhosphoSitePlus 23695679
O95983 (MBD3) S24 PhosphoSitePlus   Signor 12354758
O95983 (MBD3) S85 PhosphoSitePlus   Signor 12354758
P03372 (ESR1) S167 PhosphoSitePlus 24166501
P03372 (ESR1) S305 PhosphoSitePlus 24166501
P04637 (TP53) S106 neXtProt   PhosphoSitePlus   Signor 23201157
P04637 (TP53) S215 PhosphoSitePlus   Signor 23201157, 15469940
P04637 (TP53) S315 neXtProt   PhosphoSitePlus   Signor 24173284, 14702041, 23201157
P06748 (NPM1) S125 RLIMS-P+ 24857377
P10275 (AR) T282 PhosphoSitePlus 20713353
P10275 (AR) S293 PhosphoSitePlus 20713353
P11233 (RALA) S194 neXtProt   PhosphoSitePlus 19901077, 15637052
P12755 (SKI) S326 PhosphoSitePlus 26138431
P12755 (SKI) S383 PhosphoSitePlus 26138431
P25963 (NFKBIA) S32 neXtProt 17308110
P25963 (NFKBIA) S36 neXtProt 17308110
P30305-3 (CDC25B) S312 HPRD 15128871
P30305-2 (CDC25B) S339 HPRD 15128871
P30305 (CDC25B) S353 HPRD   neXtProt   PhosphoSitePlus   Signor 16082213, 15128871
P38398 (BRCA1) S308 HPRD   neXtProt   PhosphoSitePlus   Signor 14990569
P40337 (VHL) S72 PhosphoSitePlus 23785518
P41208 (CETN2) S122 neXtProt 21731694
P41208 (CETN2) S170 neXtProt   PhosphoSitePlus   Signor 21731694
P49450 (CENPA) S7 neXtProt   PhosphoSitePlus 14667408
P49736 (MCM2) S220 PhosphoSitePlus 20177074
P49841 (GSK3B) S9 neXtProt   PhosphoSitePlus 19060929
P53350 (PLK1) T210 neXtProt   PhosphoSitePlus   RLIMS-P+   Signor 12207013, 18615013, 24338364, ...20869364
P53667 (LIMK1) S307 neXtProt 22214762
P53667 (LIMK1) T508 neXtProt 22214762
P53671 (LIMK2) S283 neXtProt   PhosphoSitePlus 22492986
P53671 (LIMK2) T494 neXtProt   PhosphoSitePlus 22492986
P53671 (LIMK2) T505 neXtProt   PhosphoSitePlus 22492986
P57073 (SOX8) S327 Signor 32550913
P61978 (HNRNPK) S379 RLIMS-P+ 21821029
P68431 (H3C12) S11 Signor 12588998
Q02224 (CENPE) T422 neXtProt 20691903
Q13158 (FADD) S203 PhosphoSitePlus   Signor 21978935
Q13526 (PIN1) S16 PhosphoSitePlus   Signor 23970419
Q13563 (PKD2) S829 neXtProt 21670214
Q14194 (CRMP1) T101 PhosphoSitePlus 19799413
Q14194 (CRMP1) T102 PhosphoSitePlus 19799413
Q14203 (DCTN1) S19 PhosphoSitePlus 23547029
Q14511 (NEDD9) S296 neXtProt   Signor 16184168
Q14980 (NUMA1) T1804 PhosphoSitePlus 23097092
Q14980 (NUMA1) T1811 PhosphoSitePlus 23097092
Q14980 (NUMA1) T1812 PhosphoSitePlus 23097092
Q14980 (NUMA1) S1887 PhosphoSitePlus 23097092
Q14980 (NUMA1) S1969 RLIMS-P+ 26832443
Q14980 (NUMA1) S1991 PhosphoSitePlus   RLIMS-P+ 26832443, 23097092
Q14980 (NUMA1) S2047 PhosphoSitePlus   RLIMS-P+ 26832443, 23097092
Q14980 (NUMA1) T2084 PhosphoSitePlus 23097092
Q14980 (NUMA1) S2087 PhosphoSitePlus 23097092
Q15398 (DLGAP5) S627 neXtProt   PhosphoSitePlus   Signor 15987997
Q15398 (DLGAP5) S725 neXtProt   PhosphoSitePlus   Signor 15987997
Q15398 (DLGAP5) S757 neXtProt   PhosphoSitePlus   Signor 15987997
Q15398 (DLGAP5) S830 neXtProt   PhosphoSitePlus   Signor 15987997
Q49MG5 (MAP9) S305 PhosphoSitePlus 17925329
Q49MG5 (MAP9) S625 PhosphoSitePlus   Signor 20615875, 17925329
Q8IX03 (WWC1) S539 PhosphoSitePlus   Signor 21878642
Q8NHV4 (NEDD1) S405 PhosphoSitePlus   Signor 31028180, 23273898
Q8TEW0 (PARD3) S962 neXtProt   PhosphoSitePlus   Signor 19812038
Q8WV24 (PHLDA1) S95 PhosphoSitePlus   Signor 21807936
Q92974 (ARHGEF2) S886 neXtProt 17488622
Q93073 (SECISBP2L) T573 Signor 31314582
Q96CG3 (TIFA) T9 Signor 28069801
Q96CX2 (KCTD12) S243 Signor 28869606
Q96GD4 (AURKB) T232 RLIMS-P+ 26369427
Q9BQG0 (MYBBP1A) S1303 PhosphoSitePlus 20177074
Q9BXS6 (NUSAP1) S240 PhosphoSitePlus 21072059
Q9GZM8 (NDEL1) S251 neXtProt   RLIMS-P+ 17060449, 19668197
Q9HC77 (CENPJ) S467 RLIMS-P+ 26997271
Q9NRM7 (LATS2) S83 neXtProt   PhosphoSitePlus   Signor 15147269, 22904328, 21822051
Q9NRM7 (LATS2) S380 neXtProt   PhosphoSitePlus   Signor 21822051, 15147269
Q9NS23-2 (RASSF1) T202 PhosphoSitePlus 17563743, 21874044
Q9NS23-2 (RASSF1) S203 PhosphoSitePlus 17563743, 19276349, 21874044
Q9NS23 (RASSF1) T206 Signor 17563743
Q9NS23 (RASSF1) S207 Signor 17563743
Q9NWT8 (AURKAIP1) S70 RLIMS-P+   Signor 17957726
Q9ULW0 (TPX2) S121 PhosphoSitePlus   Signor 26240182
Q9ULW0 (TPX2) S125 PhosphoSitePlus   Signor 26240182
Q9UNN5 (FAF1) S289 PhosphoSitePlus   Signor 18790738
Q9UNN5 (FAF1) S291 PhosphoSitePlus   Signor 18790738
Q9UPY8 (MAPRE3) S176 PhosphoSitePlus   Signor 19696028
Q9Y657 (SPIN1) S109 Signor 22258766
Q9Y657 (SPIN1) S124 Signor 22258766
Q9Y6A5 (TACC3) S558 neXtProt   PhosphoSitePlus   RLIMS-P+   Signor 26134678, 17545617


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046439 (hAURKA/Sumo:1) suK258 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O14965 (AURKA) T287 Q9ULW0 (TPX2) unknown eFIP 21347367
Phosphorylation O15143 (ARPC1B) T21 O14965 (AURKA) unknown eFIP 20603326
Phosphorylation Q99623 (PHB2) S39 O14965 (AURKA) unknown eFIP 33820826


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:O14965 (hAURKA) Interaction PR:Q9H4B4 (hPLK3) PRO 15190214
PR:Q9H4B4 (hPLK3) Interaction PR:O14965 (hAURKA) PRO 15190214