iPTMnet Report for O14950 (MYL12B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14950 / ML12B_HUMAN
Protein Name Myosin regulatory light chain 12B
Gene Name Name: MYL12B
Synonyms:MRLC2,MYLC2B;
Organism Homo sapiens (Human)

PRO ID PR:O14950
DAG View
PRO Name myosin regulatory light chain 12B (human)
Definition A myosin regulatory light chain 12B that is encoded in the genome of human.
Short Label hMYL12B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14950 (MYL12B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T10 Phosphorylation neXtProt   PhosphoSitePlus 18835557
T10 Phosphorylation P17252 (PRKCA) neXtProt 18835557
T11 Phosphorylation PhosphoSitePlus
T19 Phosphorylation HPRD   neXtProt   PRO   PhosphoSitePlus   Signor   UniProt 11942626, 12185584, 17287340, ...18212344, 15946647, 12429016, 10356987, 1178183, 26334100, 11278951, 18835557, 11384979, 15226371, 11781833
T19 Phosphorylation O43293 (DAPK3) neXtProt   PhosphoSitePlus   Signor 12429016, 11781833, 10356987, ...1178183
T19 Phosphorylation P17252 (PRKCA) neXtProt 18835557
T19 Phosphorylation Q12852 (MAP3K12) PhosphoSitePlus   Signor 11384979, 11781833
T19 Phosphorylation Q13418 (ILK) PhosphoSitePlus   Signor 11278951
T19 Phosphorylation Q13464 (ROCK1) PhosphoSitePlus   Signor 15226371, 12185584
T19 Phosphorylation Q15746 (MYLK) PhosphoSitePlus 11781833, 26334100
S20 Phosphorylation HPRD   IEDB   neXtProt   PRO   PhosphoSitePlus   Signor   UniProt 10356987, 15226371, 16472257, ...11384979, 18452278, 18212344, 18835557, 12429016, 12571246, 15676024, 1178183, 26334100, 17056602, 12185584, 10233893, 11278951, 32387766, 18648664, 11942626, 17287340, 15946647, 11781833
S20 Phosphorylation O43293 (DAPK3) neXtProt   PhosphoSitePlus   Signor 11781833, 10356987, 1178183
S20 Phosphorylation P17252 (PRKCA) neXtProt 18835557
S20 Phosphorylation P53355 (DAPK1) PhosphoSitePlus 17056602
S20 Phosphorylation Q12852 (MAP3K12) PhosphoSitePlus 11384979
S20 Phosphorylation Q13418 (ILK) PhosphoSitePlus   Signor 11278951, 16472257
S20 Phosphorylation Q13464 (ROCK1) PhosphoSitePlus   Signor 12185584, 15676024, 15226371, ...18648664, 10233893
S20 Phosphorylation Q15746 (MYLK) PhosphoSitePlus 11781833, 12571246, 26334100
S20 Phosphorylation Q96GD4 (AURKB) PhosphoSitePlus 15676024
S29 Phosphorylation PhosphoSitePlus
K35 Acetylation PhosphoSitePlus
K51 Acetylation PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus
T97 Phosphorylation PhosphoSitePlus
C109 Methylation IEDB 31844290
T128 Phosphorylation PhosphoSitePlus
R133 Methylation PhosphoSitePlus
T135 Phosphorylation PhosphoSitePlus 6593002
T135 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 6593002
Y143 Phosphorylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K151 Sumoylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
Y156 Phosphorylation PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K168 Acetylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048496 (hMYL12B/Phos:1) pT19 PRO
PR:000048497 (hMYL12B/Phos:2) pT19,pS20 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T19 A19 Biomuta DOID:3571 / liver cancer [ cosmic ]
S60 Y60 Biomuta DOID:363 / uterine cancer [ icgc ]
C109 W109 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]