iPTMnet Report for O14939 (PLD2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14939 / PLD2_HUMAN
Protein Name Phospholipase D2
Gene Name Name: PLD2
Organism Homo sapiens (Human)

PRO ID PR:O14939
DAG View
PRO Name phospholipase D2 (human)
Definition A phospholipase D2 that is encoded in the genome of human.
Short Label hPLD2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14939 (PLD2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T29 Phosphorylation PhosphoSitePlus
T72 Phosphorylation phospho.ELM   PhosphoSitePlus 15979581
S77 Phosphorylation PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
T99 Phosphorylation phospho.ELM   PhosphoSitePlus 15979581
T100 Phosphorylation phospho.ELM   PhosphoSitePlus 15979581
Y104 Phosphorylation IEDB 35494241
K118 Ubiquitination PhosphoSitePlus
S134 Phosphorylation Q00535 (CDK5) phospho.ELM   PhosphoSitePlus 18625302, 15979581
S146 Phosphorylation phospho.ELM   PhosphoSitePlus 15979581
T156 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
Y169 Phosphorylation PhosphoSitePlus
T175 Phosphorylation PhosphoSitePlus   RLIMS-P 18006275
Y179 Phosphorylation P00533 (EGFR) PhosphoSitePlus   RLIMS-P   Signor 18006275, 9837959
S213 Phosphorylation PhosphoSitePlus
S243 Phosphorylation P17252 (PRKCA) phospho.ELM   PhosphoSitePlus   Signor 15979581
T252 Phosphorylation P17252 (PRKCA) phospho.ELM   PhosphoSitePlus   Signor 15979581
K292 Methylation PhosphoSitePlus
Y296 Phosphorylation P00533 (EGFR) neXtProt   PhosphoSitePlus   RLIMS-P 20176813
K388 Methylation PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
Y415 Phosphorylation P52333 (JAK3) neXtProt   PhosphoSitePlus   RLIMS-P+   Signor 21414324, 20176813
S416 Phosphorylation PhosphoSitePlus
T488 Phosphorylation PhosphoSitePlus
Y511 Phosphorylation P12931 (SRC) PhosphoSitePlus 20176813
T566 Phosphorylation Q05655 (PRKCD) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 20733000
Y573 Phosphorylation PhosphoSitePlus
Y578 Phosphorylation PhosphoSitePlus
Y580 Phosphorylation PhosphoSitePlus
K656 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y179 Phosphorylation P00533 (EGFR) HPRD 9837959
S609 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S77 N77 Biomuta DOID:363 / uterine cancer [ icgc ]
S79 F79 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S243 F243 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K292 E292 Biomuta DOID:1612 / breast cancer [ icgc ]
S416 R416 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S416 I416 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y580 H580 Biomuta DOID:9256 / colorectal cancer [ cosmic ]