iPTMnet Report for O14786 (NRP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14786 / NRP1_HUMAN
Protein Name Neuropilin-1 precursor
Gene Name Name: NRP1
Synonyms:NRP,VEGF165R;
Organism Homo sapiens (Human)

PRO ID PR:O14786
DAG View
PRO Name neuropilin-1 (human)
Definition A neuropilin-1 that is encoded in the genome of human.
Short Label hNRP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14786 (NRP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T30 Phosphorylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
N150 N-Glycosylation GlyGen   UniProt 16335952, 19159218, 32125861, ...24190977, 23090970, 29391424, 17989695, 29741879, 29671580
K166 Ubiquitination PhosphoSitePlus
N261 N-Glycosylation GlyGen   UniProt 17989695, 23090970, 19159218, ...29391424, 24190977
S267 Phosphorylation PhosphoSitePlus
Y297 Phosphorylation PhosphoSitePlus
Y310 Phosphorylation PhosphoSitePlus
T316 Phosphorylation PhosphoSitePlus
S321 Phosphorylation PhosphoSitePlus
Y322 Phosphorylation PhosphoSitePlus
Y353 Phosphorylation PhosphoSitePlus
Y354 Phosphorylation PhosphoSitePlus
Y358 Phosphorylation PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
T448 Phosphorylation PhosphoSitePlus
N521 N-Glycosylation GlyGen 24190977
N522 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 19159218, ...24190977
S524 Phosphorylation PhosphoSitePlus
T589 O-Glycosylation GlyGen 30459171
S612 O-Glycosylation GlyGen   UniProt 16763549, 27798666
S637 O-Glycosylation GlyGen 30459171
T638 O-Glycosylation GlyGen 30459171
T827 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T827 Phosphorylation PhosphoSitePlus
S829 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 23584533, 36213313
T830 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171
S844 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
N892 N-Glycosylation GlyGen 29391424
S894 Phosphorylation PhosphoSitePlus
Y899 Phosphorylation PhosphoSitePlus
K908 Ubiquitination PhosphoSitePlus
K913 Ubiquitination PhosphoSitePlus
T919 Phosphorylation PhosphoSitePlus
Y920 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S921 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N150 N-Glycosylation PRO 29671580
S612 O-Glycosylation PRO 16763549
S894 Phosphorylation HPRD 18578522
Y899 Phosphorylation HPRD 18578522


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036631 (hNRP1/iso:1/ClvOGlyco:1) increased Interaction PR:P15692-4 (hVEGFA/iso:VEGF165) PRO 16763549
PR:000036631 (hNRP1/iso:1/ClvOGlyco:1) Interaction PR:P35968 (hKDR) PRO 16763549
PR:000036632 (hNRP1/iso:1/ClvOGlyco:2) increased Interaction PR:P15692-4 (hVEGFA/iso:VEGF165) PRO 16763549
PR:000036632 (hNRP1/iso:1/ClvOGlyco:2) decreased Interaction PR:P35968 (hKDR) PRO 16763549
PR:000036635 (hNRP1/iso:1/SigPep-) Interaction PR:P15692-4 (hVEGFA/iso:VEGF165) PRO 11986311
PR:000036635 (hNRP1/iso:1/SigPep-) Interaction PR:P15692-4 (hVEGFA/iso:VEGF165) PRO 16763549
PR:000036635 (hNRP1/iso:1/SigPep-) Interaction PR:P49763-3 (hPGF/iso:PlGF-2) PRO 11986311
PR:000036635 (hNRP1/iso:1/SigPep-) Interaction PR:P35968 (hKDR) PRO 16763549


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T30 I30 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S47 T47 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K106 R106 Biomuta DOID:4159 / skin cancer [ cosmic ]
N150 D150 Biomuta DOID:1324 / lung cancer [ cosmic ]
S267 N267 Biomuta [ cosmic ]
T316 N316 Biomuta DOID:4159 / skin cancer [ cosmic ]
S321 F321 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
S524 L524 Biomuta DOID:1324 / lung cancer [ cosmic ]
T830 M830 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]