iPTMnet Report for O14579 (COPE)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14579 / COPE_HUMAN
Protein Name Coatomer subunit epsilon
Gene Name Name: COPE
Organism Homo sapiens (Human)

PRO ID PR:O14579
DAG View
PRO Name coatomer subunit epsilon (human)
Definition A coatomer subunit epsilon that is encoded in the genome of human.
Short Label hCOPE
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14579 (COPE) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
K23 Sumoylation PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus   UniProt 23186163
R52 Methylation PhosphoSitePlus
Y60 Phosphorylation PhosphoSitePlus
K65 Acetylation PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
Y90 Phosphorylation PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
S99 Phosphorylation IEDB   PhosphoSitePlus   UniProt 27920218, 32387766, 23186163
S109 Phosphorylation PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
Y202 Phosphorylation PhosphoSitePlus
Y203 Phosphorylation PhosphoSitePlus
C212 Methylation IEDB 31844290
S260 Phosphorylation PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
R299 Methylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation HPRD 18691976
S13 Phosphorylation HPRD 20166139, 18669648
S44 Phosphorylation HPRD 18691976, 20068231
S45 Phosphorylation HPRD 18691976
S99 Phosphorylation HPRD 20166139, 18691976, 18669648
Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation HPRD 18691976
S13 Phosphorylation HPRD 20166139, 18669648
S44 Phosphorylation HPRD 18691976, 20068231
S45 Phosphorylation HPRD 18691976
S97 Phosphorylation PhosphoSitePlus
T98 Phosphorylation PhosphoSitePlus
T101 Phosphorylation HPRD   PhosphoSitePlus 20068231
Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation HPRD 18691976
S13 Phosphorylation HPRD 20166139, 18669648
S44 Phosphorylation HPRD 18691976, 20068231
S45 Phosphorylation HPRD 18691976
S99 Phosphorylation HPRD 20166139, 18691976, 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R52 S52 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S97 G97 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S97 N97 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C212 Y212 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K288 N288 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R299 S299 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]