iPTMnet Report for O14543 (SOCS3)
Protein Information
| UniProt AC / UniProt ID | O14543 / SOCS3_HUMAN |
| Protein Name | Suppressor of cytokine signaling 3 |
| Gene Name | Name: SOCS3 Synonyms:CIS3,SSI3; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O14543 |
| PRO Name | suppressor of cytokine signaling 3 (human) |
| Definition | A suppressor of cytokine signaling 3 that is encoded in the genome of human. |
| Short Label | hSOCS3 |
| Category | organism-gene |
DAG ViewO14543 (SOCS3) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K6 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S13 | O-Glycosylation | score1 | GlyGen | 30379171 | ||
| K23 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T86 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y165 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y166 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K195 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y204 | Phosphorylation | P06239 (LCK) , O60674 (JAK2) | score3 | phospho.ELM PhosphoSitePlus RLIMS-P | 12783885 | |
| K206 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y221 | Phosphorylation | P06239 (LCK) , O60674 (JAK2) | score4 | IntAct phospho.ELM PhosphoSitePlus RLIMS-P | 12783885, 11331873, 15173187 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S13 | N13 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] |
