iPTMnet Report for O14503 (BHLHE40)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O14503 / BHE40_HUMAN
Protein Name Class E basic helix-loop-helix protein 40
Gene Name Name: BHLHE40
Synonyms:BHLHB2,DEC1,SHARP2,STRA13;
Organism Homo sapiens (Human)

PRO ID PR:O14503
DAG View
PRO Name class E basic helix-loop-helix protein 40 (human)
Definition A class E basic helix-loop-helix protein 40 that is encoded in the genome of human.
Short Label hBHLHE40
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O14503 (BHLHE40) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
K16 Ubiquitination PhosphoSitePlus
K38 Acetylation PhosphoSitePlus
K54 Acetylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K159 Sumoylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K167 Sumoylation PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
K202 Acetylation PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus   UniProt 23186163
S243 Phosphorylation PhosphoSitePlus
C260 Methylation IEDB 31844290
K262 Ubiquitination PhosphoSitePlus
K279 Sumoylation PhosphoSitePlus
R380 Methylation PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K84 E84 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S212 L212 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S243 G243 Biomuta DOID:3571 / liver cancer [ cosmic ]
S383 A383 Biomuta DOID:4606 / bile duct cancer [ cosmic ]