iPTMnet Report for O08586 (Pten)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O08586 / PTEN_MOUSE
Protein Name Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Gene Name Name: Pten
Synonyms:Mmac1;
Organism Mus musculus (Mouse)

PRO ID PR:O08586
DAG View
PRO Name phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (mouse)
Definition A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN that is encoded in the genome of mouse.
Short Label mPTEN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O08586 (Pten) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K13 Ubiquitination PhosphoSitePlus
Y46 Phosphorylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
Y174 Phosphorylation PhosphoSitePlus
Y176 Phosphorylation PhosphoSitePlus
Y177 Phosphorylation PhosphoSitePlus
Y178 Phosphorylation PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus   UniProt 21183079
T366 Phosphorylation Q9WV60 (Gsk3b) PhosphoSitePlus   RLIMS-P   UniProt 20940307, 35603900, 33039560
S370 Phosphorylation Q60737 (Csnk2a1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17242355, 24569712, 20940307
S380 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 32034125, 29775456, 19403525, ...33428810, 24569712, 14522959, 30134988, 26222260, 31474552, 33083717, 17975737, 20008297, 17875968, 29530069, 31500401, 25594415
T382 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 32034125, 19403525, 33428810, ...24569712, 20008297, 33083717, 30134988, 17875968, 29530069, 31500401, 28513223
T383 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 32034125, 19403525, 33428810, ...24569712, 30134988, 33083717, 20008297, 17875968, 29530069, 31500401, 28513223
S385 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17242355, 24569712, 33083717, ...21183079
S398 Phosphorylation PhosphoSitePlus
T401 Phosphorylation RLIMS-P 29069834


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O08586 (Pten) T366 Q9DBH0 (Wwp2) increased_association eFIP 33039560