iPTMnet Report for O00764 (PDXK)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00764 / PDXK_HUMAN
Protein Name Pyridoxal kinase
Gene Name Name: PDXK
Synonyms:C21orf124,C21orf97,PKH,PNK;ORFNames:PRED79;
Organism Homo sapiens (Human)

PRO ID PR:O00764
DAG View
PRO Name pyridoxal kinase (human)
Definition A pyridoxal kinase that is encoded in the genome of human.
Short Label hPDXK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00764 (PDXK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y18 Phosphorylation PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus   UniProt 19369195
R70 Methylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
Y84 Phosphorylation PhosphoSitePlus
C112 Methylation IEDB 31844290
K119 Ubiquitination PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
T148 Phosphorylation PhosphoSitePlus
K161 Acetylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus   UniProt 19369195
S213 Phosphorylation PhosphoSitePlus   UniProt 18691976, 19369195
K253 Ubiquitination PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
T270 Phosphorylation PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 19369195
R292 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S213 Phosphorylation HPRD 18691976
S285 Phosphorylation HPRD 18691976


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S213 F213 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K253 N253 Biomuta DOID:1324 / lung cancer [ cosmic ]
K275 N275 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
R292 Q292 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R292 W292 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]