iPTMnet Report for O00743 (PPP6C)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00743 / PPP6_HUMAN
Protein Name Serine/threonine-protein phosphatase 6 catalytic subunit
Gene Name Name: PPP6C
Synonyms:PPP6;
Organism Homo sapiens (Human)

PRO ID PR:O00743
DAG View
PRO Name serine/threonine-protein phosphatase 6 catalytic subunit (human)
Definition A serine/threonine-protein phosphatase 6 catalytic subunit that is encoded in the genome of human.
Short Label hPPP6C
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00743 (PPP6C) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K8 Ubiquitination PhosphoSitePlus
K17 Ubiquitination PhosphoSitePlus
Y18 Phosphorylation PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
R111 Methylation PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
C161 Methylation IEDB 31844290
K188 Ubiquitination PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
Y261 Phosphorylation PhosphoSitePlus
C262 Methylation IEDB 31844290
K283 Ubiquitination PhosphoSitePlus
T299 O-Glycosylation GlyGen 34229054, 35254053
T301 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S257 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K25 N25 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R111 G111 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R111 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
K132 N132 Biomuta DOID:4159 / skin cancer [ cosmic ]
S197 L197 Biomuta DOID:1319 / brain cancer [ cosmic ]
S208 T208 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K245 T245 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
T299 M299 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T301 M301 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]