iPTMnet Report for O00566 (MPHOSPH10)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00566 / MPP10_HUMAN
Protein Name U3 small nucleolar ribonucleoprotein protein MPP10
Gene Name Name: MPHOSPH10
Synonyms:MPP10;
Organism Homo sapiens (Human)

PRO ID PR:O00566
DAG View
PRO Name U3 small nucleolar ribonucleoprotein protein MPP10 (human)
Definition A U3 small nucleolar ribonucleoprotein protein MPP10 that is encoded in the genome of human.
Short Label hMPHOSPH10
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00566 (MPHOSPH10) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T10 Phosphorylation PhosphoSitePlus
T22 Phosphorylation HPRD 20068231
S37 Phosphorylation HPRD 20068231
K38 Acetylation PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
S61 Phosphorylation HPRD   PhosphoSitePlus 19691289, 20068231
S120 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 19691289, 18452278, ...19007248, 20068231
S139 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 19007248, 18452278, ...19651622, 20068231
S158 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S163 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18452278, ...19651622, 18669648, 24275569, 20068231
S167 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18452278, 19651622, 18669648, 24275569, 19690332, 20068231
S171 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17322306, 21406692, 23186163, ...17081983, 18767875, 18452278, 19651622, 18669648, 24275569, 19690332, 20068231
S178 Phosphorylation HPRD   phospho.ELM 18669648
K185 Sumoylation PhosphoSitePlus
K189 Acetylation PhosphoSitePlus
K193 Acetylation PhosphoSitePlus
K197 Acetylation PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
S208 Phosphorylation HPRD 19651622
S242 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18452278, ...19651622, 18669648, 19690332, 20068231
S275 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 21406692, 17081983, ...20068231
T280 Phosphorylation HPRD 17081983
S289 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 21406692, 17081983, ...20068231
S305 Phosphorylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
T309 Phosphorylation PhosphoSitePlus
T332 Phosphorylation PhosphoSitePlus 22267324
T332 Phosphorylation Q96GD4 (AURKB) PhosphoSitePlus 22267324
T341 Phosphorylation PhosphoSitePlus
S373 Phosphorylation PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
K382 Sumoylation PhosphoSitePlus
S399 Phosphorylation HPRD   PhosphoSitePlus 20068231
T418 O-Glycosylation GlyGen 30379171
T418 Phosphorylation HPRD 20068231
T421 O-Glycosylation GlyGen 30379171
T422 O-Glycosylation GlyGen 30379171
Y452 Phosphorylation PhosphoSitePlus
Y454 Phosphorylation PhosphoSitePlus
T459 Phosphorylation PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
Y477 Phosphorylation PhosphoSitePlus
K479 Ubiquitination PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
K498 Ubiquitination PhosphoSitePlus
S502 Phosphorylation PhosphoSitePlus
K518 Ubiquitination PhosphoSitePlus
K559 Acetylation PhosphoSitePlus
K564 Acetylation PhosphoSitePlus
K574 Acetylation PhosphoSitePlus
K609 Acetylation PhosphoSitePlus   UniProt 19608861
S629 Phosphorylation HPRD   PhosphoSitePlus 19691289
K632 Sumoylation PhosphoSitePlus
K641 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K38 M38 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K189 N189 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K193 E193 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K197 R197 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S198 P198 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S198 F198 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
K203 N203 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K203 E203 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K203 T203 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S275 R275 Biomuta DOID:1324 / lung cancer [ cosmic ]
T280 K280 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S307 L307 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ icgc ]
S373 F373 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S373 C373 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y452 C452 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S502 F502 Biomuta DOID:4159 / skin cancer [ cosmic ]
K564 Q564 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S629 F629 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic, icgc ]
K632 N632 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]