Protein Information

Cytoscape View


UniProt AC / UniProt ID O00444 / PLK4_HUMAN
Protein Name Serine/threonine-protein kinase PLK4
Gene Name Name: PLK4
Synonyms:SAK,STK18;
Organism Homo sapiens (Human)

PRO ID PR:O00444
DAG View
PRO Name serine/threonine-protein kinase PLK4 (human)
Definition A serine/threonine-protein kinase PLK4 that is encoded in the genome of human.
Short Label hPLK4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00444 (PLK4) as Substrate



Site PTM Type PTM Enzyme Source PMID
S22 Phosphorylation O00444 (PLK4) psp 21985771
T170 Phosphorylation O00444 (PLK4) psp 21985771
T174 Phosphorylation psp
Y177 Phosphorylation O00444 (PLK4) psp 21985771
S255 Phosphorylation psp
S257 Phosphorylation psp
S258 Phosphorylation psp
S266 Phosphorylation psp
S305 Phosphorylation O00444 (PLK4) psp   rlimsp 20032307, 25174401
K321 Ubiquitination psp
T323 Phosphorylation psp
S330 Phosphorylation psp
T345 Phosphorylation psp
Y377 Phosphorylation psp
S378 Phosphorylation psp
Y394 Phosphorylation psp
S401 Phosphorylation hprd   psp   uniprot 18691976, 19369195
S406 Phosphorylation psp
Y420 Phosphorylation psp
S439 Phosphorylation psp
Y495 Phosphorylation psp
K538 Acetylation psp
T547 Phosphorylation psp
S551 Phosphorylation psp
Y582 Phosphorylation psp
S589 Phosphorylation psp
T591 Phosphorylation psp
S665 Phosphorylation psp
S749 Phosphorylation psp
T751 Phosphorylation psp
S821 Phosphorylation psp
Site PTM Type PTM Enzyme Source PMID
S421 Phosphorylation hprd   pelm   psp 18691976, 18669648
S499 Phosphorylation hprd   psp 18691976
S592 Phosphorylation hprd   psp 18691976
S671 Phosphorylation hprd   psp 18691976
S817 Phosphorylation hprd   psp   uniprot 18691976, 19369195


O00444 (PLK4) as PTM Enzyme



Substrate Site Source PMID
O00444 (PLK4) S22 psp 21985771
O00444 (PLK4) T170 psp 21985771
O00444 (PLK4) Y177 psp 21985771
O00444 (PLK4) S305 psp   rlimsp 20032307, 25174401
Q15154 (PCM1) S372 psp 26755742
Q969U6 (FBXW5) S151 psp   rlimsp   uniprot 21725316
Q9HC77 (CENPJ) S595 psp   rlimsp   uniprot 20531387