iPTMnet Report for O00268 (TAF4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00268 / TAF4_HUMAN
Protein Name Transcription initiation factor TFIID subunit 4
Gene Name Name: TAF4
Synonyms:TAF2C,TAF2C1,TAF4A,TAFII130,TAFII135;
Organism Homo sapiens (Human)

PRO ID PR:O00268
DAG View
PRO Name transcription initiation factor TFIID subunit 4 (human)
Definition A transcription initiation factor TFIID subunit 4 that is encoded in the genome of human.
Short Label hTAF4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00268 (TAF4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S23 Phosphorylation PhosphoSitePlus
T47 Phosphorylation PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus   UniProt 23186163
T396 Phosphorylation PhosphoSitePlus
T409 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34725712, 27114449, 30059200, 35132862, 30620550, 31492838, 35254053, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
T409 Phosphorylation PhosphoSitePlus
S411 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34725712, 27114449, 30059200, 35132862, 30620550, 31492838, 35254053, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
S411 Phosphorylation PhosphoSitePlus
S413 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34725712, 27114449, 30059200, 35132862, 30620550, 31492838, 35254053, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
R414 Methylation PhosphoSitePlus
T415 Phosphorylation PhosphoSitePlus
S421 Phosphorylation PhosphoSitePlus
R424 Methylation PhosphoSitePlus   UniProt 24129315
R435 Methylation PhosphoSitePlus   UniProt 24129315
R491 Methylation PhosphoSitePlus
R516 Methylation PhosphoSitePlus
S528 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 35138101, 30620550, ...31492838, 35289036, 29351928, 29237092, 27114449, 34725712, 32119511, 32574038, 32938750, 35132862, 28657654, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 20068230
S528 Phosphorylation PhosphoSitePlus
T532 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34725712, 27114449, 30059200, 35132862, 30620550, 31492838, 35254053, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
T533 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34725712, 27114449, 30059200, 35132862, 30620550, 31492838, 35254053, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
S537 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34725712, 27114449, 30059200, 35132862, 30620550, 31492838, 35254053, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
T539 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34725712, 27114449, 30059200, 35132862, 30620550, 31492838, 35254053, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
S543 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34725712, 27114449, 30059200, 35132862, 30620550, 31492838, 35254053, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
S543 Phosphorylation PhosphoSitePlus
T558 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34725712, 27114449, 30059200, 35132862, 30620550, 31492838, 35254053, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
S560 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34725712, 27114449, 30059200, 35132862, 30620550, 31492838, 35254053, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
T571 Phosphorylation PhosphoSitePlus
T575 O-Glycosylation GlyGen 32938750
K611 Ubiquitination PhosphoSitePlus
K621 Ubiquitination PhosphoSitePlus
K631 Ubiquitination PhosphoSitePlus
S648 Phosphorylation PhosphoSitePlus
Y652 Phosphorylation PhosphoSitePlus
S660 Phosphorylation PhosphoSitePlus
T712 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34725712, 27114449, 30059200, 35132862, 30620550, 31492838, 35254053, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
T714 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...32938750, 35138101, 34019948, 30379171, 32574038, 34725712, 27114449, 30059200, 35132862, 30620550, 31492838, 35254053, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
S723 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34725712, 27114449, 30059200, 35132862, 30620550, 31492838, 35254053, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
T725 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34725712, 27114449, 30059200, 35132862, 30620550, 31492838, 35254053, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
T728 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...35138101, 34019948, 30379171, 32574038, 34725712, 27114449, 30059200, 35132862, 30620550, 31492838, 35254053, 32119511, 35289036, 29351928, 28657654, 29237092, 20068230
R754 Methylation PhosphoSitePlus
R769 Methylation PhosphoSitePlus
R774 Methylation PhosphoSitePlus
K795 Acetylation PhosphoSitePlus
S827 Phosphorylation PhosphoSitePlus
S857 Phosphorylation HPRD   PhosphoSitePlus 20068231
T862 Phosphorylation HPRD 20068231
K945 Ubiquitination PhosphoSitePlus
S1027 Phosphorylation PhosphoSitePlus
S1032 Phosphorylation PhosphoSitePlus
S1036 Phosphorylation PhosphoSitePlus
S1042 Phosphorylation PhosphoSitePlus
T1046 Phosphorylation PhosphoSitePlus
T1056 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T47 P47 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R414 Q414 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R491 H491 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
R491 C491 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ]
R516 W516 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R516 L516 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S528 Y528 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T533 M533 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
S543 L543 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T571 A571 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T575 M575 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K631 N631 Biomuta DOID:363 / uterine cancer [ icgc ]
S723 N723 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T725 M725 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R754 L754 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R754 Q754 Biomuta DOID:363 / uterine cancer [ icgc ]
R754 W754 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K795 N795 Biomuta DOID:4159 / skin cancer [ cosmic ]
S827 L827 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ]
S857 F857 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S857 C857 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S1032 L1032 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1036 L1036 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
S1042 L1042 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T1046 P1046 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T1056 M1056 Biomuta DOID:9256 / colorectal cancer [ cosmic ]