iPTMnet Report for O00264 (PGRMC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00264 / PGRC1_HUMAN
Protein Name Membrane-associated progesterone receptor component 1
Gene Name Name: PGRMC1
Synonyms:HPR6.6;
Organism Homo sapiens (Human)

PRO ID PR:O00264
DAG View
PRO Name membrane-associated progesterone receptor component 1 (human)
Definition A membrane-associated progesterone receptor component 1 that is encoded in the genome of human.
Short Label hPGRMC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00264 (PGRMC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R47 Methylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 18691976, 29069804, 24275569
S57 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 21406692, 23186163, ...17081983, 19369195, 29069804, 15302935, 18318008, 19367720, 18669648, 24275569, 17287340, 19690332, 20068231
T74 Phosphorylation PhosphoSitePlus   UniProt 24275569
R79 Methylation PhosphoSitePlus
K96 Acetylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
T101 Phosphorylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
K105 Acetylation PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
Y107 Phosphorylation PhosphoSitePlus
Y113 Phosphorylation PhosphoSitePlus   RLIMS-P 27448967
R119 Methylation PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
Y139 Phosphorylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
T146 Phosphorylation PhosphoSitePlus
T152 Phosphorylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
Y164 Phosphorylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
T178 Phosphorylation PhosphoSitePlus   RLIMS-P 29069804
Y180 Phosphorylation PhosphoSitePlus   RLIMS-P 29069804, 32245408, 32293262
S181 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 17287340, 29069804, ...15302935, 35137666, 18669648, 24275569, 23186163, 18088087, 20068231
K187 Ubiquitination PhosphoSitePlus
S190 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S54 Phosphorylation HPRD 18691976, 18578522, 17081983, ...19562805, 20058876, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
S57 Phosphorylation HPRD 19413330, 18691976, 18578522, ...18491316, 17287340, 20230923, 19562805, 18767875, 15302935, 18452278, 19651622, 19664994, 18669648, 20058876, 18707149, 18510355, 20166139, 19415658, 20068231
T74 Phosphorylation HPRD 20166139, 18691976, 18669648
T178 Phosphorylation HPRD 19413330, 18691976, 18491316, ...17081983, 18767875, 18452278, 20166139
Y180 Phosphorylation HPRD 18691976, 17081983, 18452278, ...19651622, 18669648, 20068231
S181 Phosphorylation HPRD 19413330, 18691976, 18578522, ...18491316, 17287340, 18767875, 15302935, 18452278, 19651622, 18669648, 18707149, 20166139, 18088087, 16565220, 19415658, 20068231, 17924679
S190 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R47 C47 Biomuta DOID:1324 / lung cancer [ cosmic ]
R47 H47 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S57 C57 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T74 P74 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
R79 W79 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K136 N136 Biomuta DOID:363 / uterine cancer [ icgc ]
T152 S152 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y180 N180 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]