iPTMnet Report for O00178 (GTPBP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O00178 / GTPB1_HUMAN
Protein Name GTP-binding protein 1
Gene Name Name: GTPBP1
Organism Homo sapiens (Human)

PRO ID PR:O00178
DAG View
PRO Name GTP-binding protein 1 (human)
Definition A GTP-binding protein 1 that is encoded in the genome of human.
Short Label hGTPBP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O00178 (GTPBP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
S8 Phosphorylation HPRD   PhosphoSitePlus 19651622
S12 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 17081983, ...19651622, 18669648
S17 Phosphorylation HPRD   PhosphoSitePlus 20230923
S24 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 20230923, 20058876, ...19664995, 19651622, 18669648, 20068231
S25 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17081983, 20230923, ...20058876, 19664995, 19651622, 18669648, 19415658, 20068231
S44 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 17081983, ...18669648, 19690332
S47 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 17081983, ...18669648, 19690332
S69 Phosphorylation PhosphoSitePlus   UniProt 23186163
T119 O-Glycosylation GlyGen 26598643
S122 O-Glycosylation GlyGen 26598643
S174 Phosphorylation PhosphoSitePlus
T175 Phosphorylation PhosphoSitePlus
T181 Phosphorylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
K258 Acetylation PhosphoSitePlus
Y259 Phosphorylation PhosphoSitePlus
T263 Phosphorylation PhosphoSitePlus
C275 Methylation IEDB 31844290
S384 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
R456 Methylation PhosphoSitePlus
T460 Phosphorylation PhosphoSitePlus
S462 Phosphorylation PhosphoSitePlus
K466 Acetylation PhosphoSitePlus
S481 Phosphorylation PhosphoSitePlus
S517 Phosphorylation PhosphoSitePlus
T523 Phosphorylation PhosphoSitePlus
R556 Methylation PhosphoSitePlus
K565 Ubiquitination PhosphoSitePlus
T569 Phosphorylation PhosphoSitePlus
T576 Phosphorylation PhosphoSitePlus
T577 Phosphorylation PhosphoSitePlus
S580 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...18669648, 20068231
S584 Phosphorylation HPRD   PhosphoSitePlus 19413330
K585 Ubiquitination PhosphoSitePlus
K590 Ubiquitination PhosphoSitePlus
S658 O-Glycosylation GlyGen 31373491
S658 Phosphorylation PhosphoSitePlus
C662 S-Nitrosylation dbSNO 26338901
T664 Phosphorylation PhosphoSitePlus
C669 S-Nitrosylation dbSNO 26338901


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S8 Y8 Biomuta DOID:4159 / skin cancer [ cosmic ]
S44 * Biomuta DOID:4362 / cervical cancer [ cosmic ]
Y259 H259 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T263 I263 Biomuta DOID:4159 / skin cancer [ cosmic ]
R456 Q456 Biomuta DOID:1612 / breast cancer [ cosmic ]
R456 W456 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S462 Y462 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S481 A481 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R556 Q556 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K585 T585 Biomuta DOID:1324 / lung cancer [ cosmic ]
S658 F658 Biomuta [ cosmic ]