iPTMnet Report for E9PCH5 (CAST)


Protein Information

Cytoscape View


UniProt AC / UniProt ID E9PCH5 / E9PCH5_HUMAN
Protein Name Calpastatin
Gene Name Name: CAST
Organism Homo sapiens (Human)

Interactive Sequence View

Select/align proteoforms across species


E9PCH5 (CAST) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S49 Phosphorylation HPRD 20068231
S86 Phosphorylation HPRD 20068231
S91 Phosphorylation HPRD 20068231
S111 Phosphorylation HPRD 19651622, 20068231
S120 Phosphorylation HPRD 17287340, 20068231
S161 Phosphorylation HPRD 18452278
S165 Phosphorylation HPRD 18452278
S166 Phosphorylation HPRD 18452278
T167 Phosphorylation HPRD 18452278
Y168 Phosphorylation HPRD 18452278
S208 Phosphorylation HPRD 19413330, 19664994, 20068231
S329 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S331 Phosphorylation HPRD 18669648, 18452278, 17081983, ...18707149
S338 Phosphorylation HPRD 18669648
S344 Phosphorylation HPRD 18669648
T375 Phosphorylation HPRD 18669648
S376 Phosphorylation HPRD 18669648
S379 Phosphorylation HPRD 20068231
S481 Phosphorylation HPRD 18669648, 20068231
S491 Phosphorylation HPRD 20068231
S526 Phosphorylation HPRD 18669648
S528 Phosphorylation HPRD 18669648, 18452278
S540 Phosphorylation HPRD 19651622, 20068231, 18452278
S542 Phosphorylation HPRD 20166139, 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S120 Y120 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S161 T161 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S165 N165 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S329 N329 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S338 L338 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S526 L526 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S542 R542 Biomuta DOID:4159 / skin cancer [ cosmic ]
S542 N542 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:3571 / liver cancer [ cosmic, icgc ]