iPTMnet Report B0YJ81 HACD1

Protein Information

Cytoscape View

UniProt AC / UniProt ID	B0YJ81 / HACD1_HUMAN
Protein Name	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1
Gene Name	Name: HACD1 Synonyms:PTPLA;
Organism	Homo sapiens (Human)

PRO ID	PR:B0YJ81 DAG View
PRO Name	very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 (human)
Definition	A very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 that is encoded in the genome of human.
Short Label	hHACD1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

B0YJ81 (HACD1) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T5	Phosphorylation		score1	PhosphoSitePlus
	S12	Phosphorylation		score1	PhosphoSitePlus
	S14	Phosphorylation		score1	PhosphoSitePlus
	S22	Phosphorylation		score2	PhosphoSitePlus UniProt	18669648
	T25	Phosphorylation		score1	PhosphoSitePlus
	S30	Phosphorylation		score1	PhosphoSitePlus
	T32	Phosphorylation		score1	PhosphoSitePlus
	S33	Phosphorylation		score1	PhosphoSitePlus
	K109	Ubiquitination		score1	PhosphoSitePlus
	S235	Phosphorylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S22	Phosphorylation		score0	HPRD	18669648, 20068231
	T25	Phosphorylation		score0	HPRD	20068231
	S30	Phosphorylation		score0	HPRD	18669648, 20068231
	T32	Phosphorylation		score0	HPRD	18669648, 20068231
	S33	Phosphorylation		score0	HPRD	20068231

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
T25	R25	Biomuta		DOID:1612 / breast cancer [ cosmic, icgc ]
K109	T109	Biomuta		DOID:9256 / colorectal cancer [ icgc ]