iPTMnet Report for A0MZ66 (SHTN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID A0MZ66 / SHOT1_HUMAN
Protein Name Shootin-1
Gene Name Name: SHTN1
Synonyms:KIAA1598;
Organism Homo sapiens (Human)

PRO ID PR:A0MZ66
DAG View
PRO Name shootin-1 (human)
Definition A shootin-1 that is encoded in the genome of human.
Short Label hSHTN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


A0MZ66 (SHTN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
S4 Phosphorylation PhosphoSitePlus   UniProt 23186163
S15 Phosphorylation PhosphoSitePlus
K17 Ubiquitination PhosphoSitePlus
Y24 Phosphorylation PhosphoSitePlus
K35 Acetylation PhosphoSitePlus
K37 Acetylation PhosphoSitePlus
K51 Acetylation PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus   RLIMS-P 26261183
Y104 Phosphorylation PhosphoSitePlus
K169 Methylation PhosphoSitePlus
Y214 Phosphorylation PhosphoSitePlus
S233 Phosphorylation PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 26261183, 23186163, 20068231
K271 Ubiquitination PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S384 Phosphorylation PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus
K406 Acetylation PhosphoSitePlus
K406 Methylation PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
R416 Methylation PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
T455 Phosphorylation PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus
S464 Phosphorylation PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
S467 Phosphorylation PhosphoSitePlus
S473 Phosphorylation PhosphoSitePlus   UniProt 23186163
T475 Phosphorylation PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus
T487 Phosphorylation PhosphoSitePlus   UniProt 23186163
S492 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S493 Phosphorylation PhosphoSitePlus
S494 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
T496 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S506 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...24275569, 19690332, 20068231
S512 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S515 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K524 Ubiquitination PhosphoSitePlus
S532 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S534 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T537 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243, ...20068231
S562 O-Glycosylation GlyGen 23301498, 30379171, 28510447, ...31373491, 35008409
K616 Ubiquitination PhosphoSitePlus
S619 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S249 Phosphorylation HPRD 19651622, 20068231
S337 Phosphorylation HPRD 18452278
T398 Phosphorylation HPRD 20068231
T399 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K89 M89 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y104 N104 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T399 S399 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K406 M406 Biomuta DOID:1319 / brain cancer [ cosmic ]
R416 I416 Biomuta DOID:363 / uterine cancer [ icgc ]
S467 F467 Biomuta DOID:4159 / skin cancer [ cosmic ]
K485 N485 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T496 N496 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S506 Y506 Biomuta DOID:3571 / liver cancer [ cosmic ]